p65 inhibitor triptolide Search Results


p65 inhibitor triptolide  (MedChemExpress)
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MedChemExpress p65 inhibitor triptolide
A Representative immunohistochemical staining of DDX41 in OSCC compared to adjacent normal tissues (Scale bar, 50 μm). B Quantitative tissue scoring of DDX41 protein expression in control tissues ( n = 10) and OSCC tissues ( n = 54). C Kaplan–Meier analysis shows that DDX41 expression is significantly associated with overall survival in OSCC patients (DDX41 low, n = 34; DDX41 high, n = 20; p = 0.0347) . D – G Representative immunohistochemical staining of DDX41 and <t>p-p65/PD-L1/CD33/CD8</t> in OSCC (Scale bar, 50 μm). H , I Correlation of DDX41 and p-p65/PD-L1 in OSCC tissue microarrays (p-p65 p < 0.0001, r = 0.5969)/ (PD-L1 p < 0.001, r = 0.4577). J , K , N , O Quantitative tissue scoring of p-p65/PD-L1/CD33/CD8 protein expression in control tissues ( n = 10) and OSCC tissues ( n = 54). L, M Correlation of DDX41 and CD33/CD8 in OSCC tissue microarrays (CD33 p < 0.0001, r = 0.6567) / (CD8 p < 0.0001, r = 0.6099). P Heat map of the correlation of protein expression among DDX41, p-p65, CD33, PD-L1 and CD8. The quantitative data above are presented as mean ± SEM; * p < 0.05, ** p < 0.01, *** p < 0.001.
P65 Inhibitor Triptolide, supplied by MedChemExpress, used in various techniques. Bioz Stars score: 95/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
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A Representative immunohistochemical staining of DDX41 in OSCC compared to adjacent normal tissues (Scale bar, 50 μm). B Quantitative tissue scoring of DDX41 protein expression in control tissues ( n = 10) and OSCC tissues ( n = 54). C Kaplan–Meier analysis shows that DDX41 expression is significantly associated with overall survival in OSCC patients (DDX41 low, n = 34; DDX41 high, n = 20; p = 0.0347) . D – G Representative immunohistochemical staining of DDX41 and p-p65/PD-L1/CD33/CD8 in OSCC (Scale bar, 50 μm). H , I Correlation of DDX41 and p-p65/PD-L1 in OSCC tissue microarrays (p-p65 p < 0.0001, r = 0.5969)/ (PD-L1 p < 0.001, r = 0.4577). J , K , N , O Quantitative tissue scoring of p-p65/PD-L1/CD33/CD8 protein expression in control tissues ( n = 10) and OSCC tissues ( n = 54). L, M Correlation of DDX41 and CD33/CD8 in OSCC tissue microarrays (CD33 p < 0.0001, r = 0.6567) / (CD8 p < 0.0001, r = 0.6099). P Heat map of the correlation of protein expression among DDX41, p-p65, CD33, PD-L1 and CD8. The quantitative data above are presented as mean ± SEM; * p < 0.05, ** p < 0.01, *** p < 0.001.

Journal: NPJ Precision Oncology

Article Title: DDX41 facilitates PD-L1-mediated immune escape in OSCC via the phase separation and activation STING pathway

doi: 10.1038/s41698-026-01308-1

Figure Lengend Snippet: A Representative immunohistochemical staining of DDX41 in OSCC compared to adjacent normal tissues (Scale bar, 50 μm). B Quantitative tissue scoring of DDX41 protein expression in control tissues ( n = 10) and OSCC tissues ( n = 54). C Kaplan–Meier analysis shows that DDX41 expression is significantly associated with overall survival in OSCC patients (DDX41 low, n = 34; DDX41 high, n = 20; p = 0.0347) . D – G Representative immunohistochemical staining of DDX41 and p-p65/PD-L1/CD33/CD8 in OSCC (Scale bar, 50 μm). H , I Correlation of DDX41 and p-p65/PD-L1 in OSCC tissue microarrays (p-p65 p < 0.0001, r = 0.5969)/ (PD-L1 p < 0.001, r = 0.4577). J , K , N , O Quantitative tissue scoring of p-p65/PD-L1/CD33/CD8 protein expression in control tissues ( n = 10) and OSCC tissues ( n = 54). L, M Correlation of DDX41 and CD33/CD8 in OSCC tissue microarrays (CD33 p < 0.0001, r = 0.6567) / (CD8 p < 0.0001, r = 0.6099). P Heat map of the correlation of protein expression among DDX41, p-p65, CD33, PD-L1 and CD8. The quantitative data above are presented as mean ± SEM; * p < 0.05, ** p < 0.01, *** p < 0.001.

Article Snippet: The STING inhibitor C-176 and the p65 inhibitor triptolide were purchased from MCE (C-176 MCE HY-112906, Triptolide HY-32735).

Techniques: Immunohistochemical staining, Staining, Expressing, Control